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Burkholderia pseudomallei grown on sheep blood agar for 48 hours. An atypical enlarged lymphocyte found in the blood smear from a HPS patient.A salivary gland that had been extracted from a mosquito, which was infected by the Eastern equine encephalitis (EEE) virus, which has been colorized red. Unidentified mosquito larvae scattered uniformly over a dark background.

ANIMAL MODELS CORE

 


Animal Modeling and Telepathology Core

Paul Luciw, University of California, Davis

Abstract:

The objective of the Animal Modeling and Telepathology Core is to offer a broad array of animal modeling expertise, technical support, and instrumentation to the scientific community that is involved in responding to national research initiatives in biodefense and infectious disease.  We coordinate access of RCE investigators to a broad array of existing core resources and expertise in animal modeling at UC Davis, including the Center for Comparative Medicine, the UC Davis Mouse Biology Program, the California National Primate Research Center (including the Respiratory Biology Laboratory and Non-human Primate Immunology Core), the Center for Vector Borne Diseases, and others.  The Core is centrally administered through the UC Davis Center for Comparative Medicine, and provides access for RCE investigators to expertise in comparative and experimental pathology through an innovative telepathology system, which links all RCE sites and facilitates inter-institutional communication.  Our mission is to stimulate and facilitate collaborative research interactions among RCE investigators and scientists needing expertise in animal modeling, in order to leverage RCE support into independent research programs that foster the NIH research mission in biodefense and emerging infectious disease research.
 
Details of Core Services are contained in the website: http://pswrce.compmed.ucdavis.edu/  

  • Histopathology (tissue processing, staining, immunohistochemistry, in situ hybridization)
  • Laser-capture Microdissection
  • Analysis by Tissue Arrays
  • Whole Slide Imaging
  • Telepathology (pathology databases, conferencing)
  • Multiplex Microbead Immunoassays (for antibodies, cytokines, chemokines, etc; Luminex and BioPlex systems)
  • Multiparameter Flow Cytometry and Cell Sorting
  • Consultation:  Importantly, a team of highly experienced individuals at UC Davis is available for consultation at all levels, including planning experiments, designing experimental protocols, data analysis and storage, and networking to exchange data.   

BSL-3 Animal Modeling Core
 

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