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With a newly-obtained fiery red blood meal visible through her transparent abdomen, the now heavy female Aedes aegypti mosquito takes flight. Clostridium botulinum growing on egg yolk agar showing the lipase reaction.An atypical enlarged lymphocyte found in the blood smear from a HPS patient. (a) An atypical enlarged lymphocyte found in the blood smear from a HPS patient. (b)Burkholderia psudeomallei grown on sheep blood agar for 24 hours.

Animal Models Core

Animal resources and laboratory services core

Paul Luciw, University of California, Davis

The objective of the Animal Modeling and Telepathology Core is to offer a broad array of animal modeling expertise, technical support, and instrumentation to the scientific community that is involved in responding to national research initiatives in biodefense and infectious disease. We coordinate access of RCE investigators to a broad array of existing core resources and expertise in animal modeling at UC Davis, including the Center for Comparative Medicine, the UC Davis Mouse Biology Program, the California National Primate Research Center (including the Respiratory Biology Laboratory and Non-human Primate Immunology Core), the Center for Vector Borne Diseases, and others. The Core is centrally administered through the UC Davis Center for Comparative Medicine, and provides access for RCE investigators to expertise in comparative and experimental pathology through an innovative telepathology system, which links all RCE sites and facilitates inter-institutional communication. Our mission is to stimulate and facilitate collaborative research interactions among RCE investigators and scientists needing expertise in animal modeling, in order to leverage RCE support into independent research programs that foster the NIH research mission in biodefense and emerging infectious disease research.

Details of Core Services are contained in the website:

  • Histopathology (tissue processing, staining, immunohistochemistry, in situ hybridization)
  • Laser-capture microdissection
  • Tissue array analysis
  • Whole slide imaging
  • Telepathology (website design, pathology databases, conferencing)
  • Multiplex microbead immunoassays (detection of antibodies and host response proteins including cytokines, chemokines)
  • Statistical analysis and computational modeling (for biomarkers)
  • Good Laboratory Practices (GLP) certification at the California National Primate Research Center; BSL-3 Laboratory (for infectious pathogens, including select agents)
  • aBSL-3 Facility (for infectious pathogen/toxin studies in nonhuman primates
  • Consultation (study planning; designing experimental protocols; data analysis, storage, exchange; computational modeling)


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